NFL Odds

NFL Week 1 Odds for Every Game

Peter Dewey
May 12, 2021, 1:25 PM EDT
The Colts and Seahawks face off in Week 1.
The Colts and Seahawks face off in Week 1. / Jonathan Ferrey/Getty Images
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The NFL fed all of our obsessions by releasing the Week 1 schedule Wednesday morning ahead of tonight’s full reveal. 

Tom Brady and the Tampa Bay Buccaneers will kickoff the 2021 season in primetime against Dak Prescott and the Dallas Cowboys on Thursday Night Football. That’s just one of the many intriguing matchups in Week 1.

The adrenaline is pumping and Vegas is helping us keep it going, as WynnBET released its odds for every game in Week 1. Here are the lines.

NFL Week 1 Odds

Dallas Cowboys at Tampa Bay Buccaneers Odds

Spread: 

Bucs -6.5 (-110)

Cowboys +6.5 (-110)

Moneyline: 

Bucs: -290

Cowboys: +245

Over/Under: 52 (Over: -110/Under: -110)

Philadelphia Eagles at Atlanta Falcons Odds

Spread: 

Falcons -4 (-110)

Eagles +4: (-110)

Moneyline: 

Falcons: -190

Eagles: +170

Over/Under: 47 (Over: -110/Under: -110)

Pittsburgh Steelers at Buffalo Bills Odds

Spread:

Bills -6.5 (-110)

Steelers +6.5 (-110)

Moneyline: 

Bills: -270

Steelers: +230

Over/Under: 50 (Over: -110/Under: -110)

New York Jets at Carolina Panthers Odds

Spread: 

Panthers -4 (-110)

Jets +4 (-110)

Moneyline: 

Panthers: -180

Jets: +160

Over/Under: 43 (Over: -110/Under: -110)

Minnesota Vikings at Cincinnati Bengals Odds

Spread: 

Vikings -3 (-110)

Bengals +3 (-110)

Moneyline: 

Vikings: -155

Bengals: +135

Over/Under: 48 (Over: -110/Under: -110)

San Francisco 49ers at Detroit Lions Odds

Spread: 

49ers -7.5: (-110)

Lions +7.5 (-110)

Moneyline: 

49ers: -360

Lions: +290

Over/Under: 45.5 (Over: -110/Under: -110)

Jacksonville Jaguars at Houston Texans Odds

Spread: 

Jaguars -2.5 (-120)

Texans +2.5 (+100)

Moneyline: 

Jaguars: -140

Texans: +120

Over/Under: 45 (Over: -110/Under: -110)

Seattle Seahawks at Indianapolis Colts Odds

Spread:

Seahawks +2.5 (+100)

Colts -2.5 (-120)

Moneyline: 

Seahawks: +115

Colts: -135

Over/Under: 52 (Over: -110/Under: -110)

Arizona Cardinals at Tennessee Titans Odds

Spread: 

Cardinals +2.5 (+100)

Titans -2.5 (-120)

Moneyline: 

Cardinals: +130

Titans: -150

Over/Under: 50.5 (Over: -110/Under: -110)

Los Angeles Chargers at Washington Football Team Odds

Spread: 

Washington +0.0 (-110)

Chargers -0.0 (-110)

Moneyline: 

Washington: -110

Chargers: -110

Over/Under: 44.5 (Over: -110/Under: -110)

Cleveland Browns at Kansas City Chiefs Odds

Spread: 

Chiefs -5.5 (-110)

Browns +5.5 (-110)

Moneyline: 

Chiefs: -250

Browns: +210

Over/Under: 53 (Over: -110/Under: -110)

Miami Dolphins at New England Patriots Odds

Spread: 

Dolphins +2.5 (-110)

Patriots -2.5 (-110)

Moneyline: 

Dolphins: +120

Patriots: -140

Over/Under: 45.5 (Over: -110/Under: -110)

Denver Broncos at New York Giants Odds

Spread: 

Broncos -0.0 (-110)

Giants +0.0 (-110)

Moneyline: 

Broncos: -110

Giants: -110

Over/Under: 42.5 (Over: -110/Under: -110)

Chicago Bears at Los Angeles Rams Odds

Spread: 

Bears +7.5 (-120)

Rams -7.5 (+100)

Moneyline: 

Bears: +290

Rams: -360

Over/Under: 44.5 (Over: -110/Under: -110)

Baltimore Ravens at Las Vegas Raiders Odds

Spread:

Ravens -5 (-110)

Raiders +5 (-110)

Moneyline:

Ravens: -230

Raiders: +195

Over/Under: 52 (Over: -110/Under: -110)

This post will be updated once odds for the Green Bay Packers at New Orleans Saints game are available on WynnBET.

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